Scientific Program
The Group’s scientific program includes all phases of clinical research (phases 1 to 4). It also covers all types and subtypes of breast cancer: Hormone-receptor-positive – estrogen or progesterone (HR +); HER2 protein overexpression (HER2 +); Triple-negative, which does not involve hormone receptors nor those of the HER2 protein (HR- / HER2-); Genetic mutation (somatic / spontaneous or hereditary / transmitted), as well as all stages of the disease or extent of cancer, from in situ and early stages to metastatic cancer.
| Cancer Subtype | Time of treatment | Treatment Types |
|---|---|---|
| HR+/HER2- | Neoadjuvant | Chemotherapy |
| HR-/HER2+ | Adjuvant | Hormonal therapy |
| HR-/HER2- (mutated or not) | Post-Neoadjuvant | Immunotherapy |
| HR+/HER2+ | Prevention | |
| Genetic Mutations | Radiation therapy | |
| Supportive therapy | ||
| Surgery | ||
| Targeted therapy |
Clinical Trials Performed Within the Group
The consortium is presently involved in over 40 or so clinical trials and is considering new ones regularly. Please refer to the table below which only lists trials that are currently in preparation or in recruitment at the Group’s hospitals.
How to use this table:
– Use the arrows to sort the columns in alphabetical order (in particular to sort the studies by status)
– Use the Search field with any keyword (hospital centre, cancer subtype etc.)
| Cancer Subtype | Study Name | Sponsor | Participating Hospitals | Status |
|---|---|---|---|---|
| HR+ & HER2- | KEYNOTE-B49 A Randomized, Double-blind, Placebo-controlled, Phase 3 Study of Pembrolizumab Plus Chemotherapy Versus Placebo Plus Chemotherapy for the Treatment of Chemotherapy-Candidate Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor2-Negative (HR+/HER2-) Metastatic Breast Cancer (KEYNOTE-B49) | Merck | CIUSSS DU CENTRE-OUEST-DE-L'ILE-DE-MONTREAL/ JEWISH GENERAL HOSPITAL CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CHUM) CHU DE QUEBEC – UNIVERSITE LAVAL | In recruitment |
| HER2+ | DESTINY-Breast09 Phase III, double-blind, randomised study assessing the efficacy of capivasertib + fulvestrant vs placebo + fulvestrant for the treatment of patients with locally advanced (inoperable) or metastatic Hormone Receptor Positive, Human Epidermal Growth Factor Receptor 2 Negative (HR+/HER2-) breast cancer following recurrence or progression on or after aromatase inhibitor (AI) therapy | AstraZeneca | CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CHUM) MCGILL UNIVERSITY HEALTH CENTER (MUHC) CIUSSS DE L'EST-DE-L'ILE-DE-MONTREAL/ HÔPITAL MAISONNEUVE-ROSEMONT CIUSSS DE L'OUEST-DE-L'ILE-DE-MONTREAL/ ST. MARY'S HOSPITAL | In recruitment |
| HER2+ | DESTINY-Breast11 A phase III trial of neoadjuvant Trastuzumab Deruxtecan monotherapy or Trastuzumab Deruxtecan in sequence with paclitaxel + trastuzumab + pertuzumab vs doxorubicin + cyclophosphamide followed by paclitaxel + trastuzumab + pertuzumab in HER2-positive early breast cancer (Destiny-11) | AstraZeneca | CIUSSS DU CENTRE-OUEST-DE-L'ILE-DE-MONTREAL/ JEWISH GENERAL HOSPITAL MCGILL UNIVERSITY HEALTH CENTER (MUHC) CHU DE QUEBEC – UNIVERSITE LAVAL CIUSSS DE L'ESTRIE - CHUS | In recruitment |
| HR+/HER2- | SERENA-6 A phase 3, double-bliind, randomized study to assess the efficacy and safety of switching to AZD9833 (an oral SERD) + CDK4/6 inhibitors (palbociclib or abemaciclib) vs continuing aromatase inhibitor + CDK4/6 inhibitors in patients with acquired ESR1 mutation without radiological progression during 1L treatment with AI + CDK4/6i for ER+/HER2- mBC-ctDNA guided early switch study | AstraZeneca | CIUSSS DU CENTRE-OUEST-DE-L'ILE-DE-MONTREAL/ JEWISH GENERAL HOSPITAL CHU DE QUEBEC – UNIVERSITE LAVAL CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CHUM) CIUSSS DE L'EST-DE-L'ILE-DE-MONTREAL/ HOPITAL MAISONNEUVE-ROSEMONT | In recruitment |
| HR+/HER2- | SERENA-4 A Randomised, Multicentre, Double-Blind, Phase III Study of AZD9833 (an Oral SERD) Plus Palbociclib Versus Anastrozole Plus Palbociclib for the Treatment of Patients With Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease | AstraZeneca | CIUSSS DU CENTRE-OUEST-DE-L'ILE-DE-MONTREAL/ JEWISH GENERAL HOSPITAL | In recruitment |
| HR+/HER2- | CAPItello-292 A Randomised, Multicentre, Double-Blind, Phase III Study of AZD9833 (an Oral SERD) Plus Palbociclib Versus Anastrozole Plus Palbociclib for the Treatment of Patients With Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease | AstraZeneca | CIUSSS DU CENTRE-OUEST-DE-L'ILE-DE-MONTREAL/ JEWISH GENERAL HOSPITAL CIUSSS SAGUENAY-LAC-ST-JEAN / HÔPITAL DE CHICOUTIMI | In recruitment |
| HER2+ | HER2CLIMB-05 A Randomized, Double-blind, Phase 3 Study of Tucatinib or Placebo in Combination With Trastuzumab and Pertuzumab as Maintenance Therapy for Metastatic HER2+ Breast Cancer | Seagen | CIUSSS DU CENTRE-OUEST-DE-L'ILE-DE-MONTREAL/ JEWISH GENERAL HOSPITAL CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CHUM) CIUSSS DU SAGUENAY-LAC-SAINT-JEAN / HÔPITAL DE CHICOUTIMI | In recruitment |
| HER2+ | MO43110 A Phase IIIB, Multinational, Multicenter, Randomized, Open-Label Study to Evaluate Patient Preference for Home Administration of Fixed-Dose Combination of Pertuzumab and Trastuzumab for Subcutaneous Administration in Participants With Early or Locally Advanced/Inflammatory HER2-Positive Breast Cancer | Hoffmann-LaRoche | CIUSSS DU CENTRE-OUEST-DE-L'ILE-DE-MONTREAL / HOPITAL GENERAL JUIF CHU DE QUEBEC – UNIVERSITE LAVAL | In recruitment |
| HR- & HER2- (triple negative) | TROPION-Breast-02 A Phase 3, Open-label, Randomised Study of Datopotamab Deruxtecan (Dato-DXd) Versus Investigator's Choice of Chemotherapy in Patients Who Are Not Candidates for PD-1/PD-L1 Inhibitor Therapy in First-line Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION Breast02) | AstraZeneca | CHU DE QUEBEC - UNIVERSITÉ LAVAL CENTRE UNIVERSITAIRE DE SANTÉ MCGILL (CUSM) CISSS MONTÉRÉGIE CENTRE / HÔPITAL CHARLES-LEMOYNE | In recruitment |
| HR- & HER2- (triple negative) | TROPION-Breast-03 A Study of Dato-DXd With or Without Durvalumab Versus Investigator’s Choice of Therapy in Patients With Stage I-III Triple-negative Breast Cancer Without Pathological Complete Response at the Time of Surgery Following Neoadjuvant Therapy | AstraZeneca | CIUSSS DU CENTRE-OUEST-DE-L'ILE-DE-MONTREAL / HOPITAL GENERAL JUIF CHU DE QUEBEC - UNIVERSITÉ LAVAL CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CHUM) CENTRE UNIVERSITAIRE DE SANTÉ MCGILL (CUSM) | In recruitment |
| HR+ & HER2- | CELC-G-301 (Description en français à venir) Phase 3, Open-Label, Randomized, Study Comparing Gedatolisib Combined With Fulvestrant & With or Without Palbociclib to Standard-of-Care Therapies in Patients With HR-Positive, HER2-Negative Advanced Breast Cancer Previously Treated With a CDK4/6 Inhibitor in Combination w/Non-Steroidal Aromatase Inhibitor Therapy | Celcuity | CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CHUM) CIUSSS DE L'EST-DE-L'ILE-DE-MONTREAL/ HOPITAL MAISONNEUVE-ROSEMONT CIUSSS SAGUENAY-LAC-ST-JEAN / HÔPITAL DE CHICOUTIMI | In recruitment |
| HR+ & HER2- | CAMBRIA-1 (Description en français à venir) A Phase III, Open-Label, Randomised Study to Assess the Efficacy and Safety of Extended Therapy With Camizestrant Versus Standard Endocrine Therapy (Aromatase Inhibitor or Tamoxifen) in Patients With ER+/HER2- Early Breast Cancer | Astra Zeneca | CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CHUM) CENTRE UNIVERSITAIRE DE SANTÉ MCGILL (CUSM) CIUSSS DE L'EST-DE-L'ILE-DE-MONTREAL/ HOPITAL MAISONNEUVE-ROSEMONT | In preparation |
| HR- & HER2- (triple négatif) | TROPION-B04 A Phase III, Open-label, Randomised Study of Neoadjuvant Datopotamab Deruxtecan (Dato DXd) Plus Durvalumab Followed by Adjuvant Durvalumab With or Without Chemotherapy Versus Neoadjuvant Pembrolizumab Plus Chemotherapy Followed by Adjuvant Pembrolizumab With or Without Chemotherapy for the Treatment of Adult Patients with Untreated Triple-Negative or Hormone Receptor low/HER2-negative Breast Cancer | Astra Zeneca | CIUSSS DU CENTRE-OUEST-DE-L'ILE-DE-MONTREAL/ JEWISH GENERAL HOSPITAL CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CHUM) CENTRE UNIVERSITAIRE DE SANTÉ MCGILL (CUSM) CIUSSS DE L'EST-DE-L'ILE-DE-MONTREAL/ HOPITAL MAISONNEUVE-ROSEMONT CIUSSS DE L'ESTRIE - CHUS CISSS DE CHAUDIÈRE-APPALACHES | In recruitment |
| HR+ & HER2- | INAVO-121 A Phase III, Multicenter, Randomized, Open-Label Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Versus Alpelisib Plus Fulvestrant in Patients With Hormone Receptor-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Who Progressed During or After CDK4/6 Inhibitor and Endocrine Combination Therapy | Hoffmann-LaRoche | CIUSSS DU CENTRE-OUEST-DE-L'ILE-DE-MONTREAL / HOPITAL GENERAL JUIF CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CHUM) CIUSSS DE L'EST-DE-L'ILE-DE-MONTREAL / HOPITAL MAISONNEUVE-ROSEMONT CIUSSS DU NORD-DE-L’ÎLE-DE-MONTRÉAL / HÔPITAL DU SACRÉ-CŒUR-DE-MONTRÉAL | In recruitment |
| HR+ or HR- & HER2+ | INAVO-122 A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo As Maintenance Therapy After First Line Induction Therapy in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer | Hoffmann-LaRoche | CIUSSS DU CENTRE-OUEST-DE-L'ILE-DE-MONTREAL / HOPITAL GENERAL JUIF CHU DE QUEBEC - UNIVERSITÉ LAVAL CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CHUM) CIUSSS DU NORD-DE-L’ÎLE-DE-MONTRÉAL / HÔPITAL DU SACRÉ-CŒUR-DE-MONTRÉAL | In recruitment |
| HR+ & HER2- | pionERA Breast Cancer A Phase III, randomized, open-label multicenter study that will evaluate the efficacy and safety of giredestrant compared with fulvestrant, both in combination with the investigator's choice of a CDK4/6 inhibitor (palbociclib, ribociclib or abemaciclib), in participants with estrogen receptor-positive (ER+), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer who have developed resistance to adjuvant endocrine therapy. | Hoffmann-LaRoche | CHU DE QUEBEC - UNIVERSITÉ LAVAL CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CHUM) CENTRE UNIVERSITAIRE DE SANTÉ MCGILL (CUSM) CIUSSS SAGUENAY-LAC-ST-JEAN / HÔPITAL DE CHICOUTIMI | In recruitment |
| Cancer Subtype | Study Name | Sponsor | Participating Hospitals | Status |
|---|---|---|---|---|
| HR+ & HER2- | KEYNOTE-B49 A Randomized, Double-blind, Placebo-controlled, Phase 3 Study of Pembrolizumab Plus Chemotherapy Versus Placebo Plus Chemotherapy for the Treatment of Chemotherapy-Candidate Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor2-Negative (HR+/HER2-) Metastatic Breast Cancer (KEYNOTE-B49) | Merck | CIUSSS DU CENTRE-OUEST-DE-L'ILE-DE-MONTREAL/ JEWISH GENERAL HOSPITAL CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CHUM) CHU DE QUEBEC – UNIVERSITE LAVAL | In recruitment |
| HER2+ | DESTINY-Breast09 Phase III, double-blind, randomised study assessing the efficacy of capivasertib + fulvestrant vs placebo + fulvestrant for the treatment of patients with locally advanced (inoperable) or metastatic Hormone Receptor Positive, Human Epidermal Growth Factor Receptor 2 Negative (HR+/HER2-) breast cancer following recurrence or progression on or after aromatase inhibitor (AI) therapy | AstraZeneca | CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CHUM) MCGILL UNIVERSITY HEALTH CENTER (MUHC) CIUSSS DE L'EST-DE-L'ILE-DE-MONTREAL/ HÔPITAL MAISONNEUVE-ROSEMONT CIUSSS DE L'OUEST-DE-L'ILE-DE-MONTREAL/ ST. MARY'S HOSPITAL | In recruitment |
| HER2+ | DESTINY-Breast11 A phase III trial of neoadjuvant Trastuzumab Deruxtecan monotherapy or Trastuzumab Deruxtecan in sequence with paclitaxel + trastuzumab + pertuzumab vs doxorubicin + cyclophosphamide followed by paclitaxel + trastuzumab + pertuzumab in HER2-positive early breast cancer (Destiny-11) | AstraZeneca | CIUSSS DU CENTRE-OUEST-DE-L'ILE-DE-MONTREAL/ JEWISH GENERAL HOSPITAL MCGILL UNIVERSITY HEALTH CENTER (MUHC) CHU DE QUEBEC – UNIVERSITE LAVAL CIUSSS DE L'ESTRIE - CHUS | In recruitment |
| HR+/HER2- | SERENA-6 A phase 3, double-bliind, randomized study to assess the efficacy and safety of switching to AZD9833 (an oral SERD) + CDK4/6 inhibitors (palbociclib or abemaciclib) vs continuing aromatase inhibitor + CDK4/6 inhibitors in patients with acquired ESR1 mutation without radiological progression during 1L treatment with AI + CDK4/6i for ER+/HER2- mBC-ctDNA guided early switch study | AstraZeneca | CIUSSS DU CENTRE-OUEST-DE-L'ILE-DE-MONTREAL/ JEWISH GENERAL HOSPITAL CHU DE QUEBEC – UNIVERSITE LAVAL CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CHUM) CIUSSS DE L'EST-DE-L'ILE-DE-MONTREAL/ HOPITAL MAISONNEUVE-ROSEMONT | In recruitment |
| HR+/HER2- | SERENA-4 A Randomised, Multicentre, Double-Blind, Phase III Study of AZD9833 (an Oral SERD) Plus Palbociclib Versus Anastrozole Plus Palbociclib for the Treatment of Patients With Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease | AstraZeneca | CIUSSS DU CENTRE-OUEST-DE-L'ILE-DE-MONTREAL/ JEWISH GENERAL HOSPITAL | In recruitment |
| HR+/HER2- | CAPItello-292 A Randomised, Multicentre, Double-Blind, Phase III Study of AZD9833 (an Oral SERD) Plus Palbociclib Versus Anastrozole Plus Palbociclib for the Treatment of Patients With Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease | AstraZeneca | CIUSSS DU CENTRE-OUEST-DE-L'ILE-DE-MONTREAL/ JEWISH GENERAL HOSPITAL CIUSSS SAGUENAY-LAC-ST-JEAN / HÔPITAL DE CHICOUTIMI | In recruitment |
| HER2+ | HER2CLIMB-05 A Randomized, Double-blind, Phase 3 Study of Tucatinib or Placebo in Combination With Trastuzumab and Pertuzumab as Maintenance Therapy for Metastatic HER2+ Breast Cancer | Seagen | CIUSSS DU CENTRE-OUEST-DE-L'ILE-DE-MONTREAL/ JEWISH GENERAL HOSPITAL CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CHUM) CIUSSS DU SAGUENAY-LAC-SAINT-JEAN / HÔPITAL DE CHICOUTIMI | In recruitment |
| HER2+ | MO43110 A Phase IIIB, Multinational, Multicenter, Randomized, Open-Label Study to Evaluate Patient Preference for Home Administration of Fixed-Dose Combination of Pertuzumab and Trastuzumab for Subcutaneous Administration in Participants With Early or Locally Advanced/Inflammatory HER2-Positive Breast Cancer | Hoffmann-LaRoche | CIUSSS DU CENTRE-OUEST-DE-L'ILE-DE-MONTREAL / HOPITAL GENERAL JUIF CHU DE QUEBEC – UNIVERSITE LAVAL | In recruitment |
| HR- & HER2- (triple negative) | TROPION-Breast-02 A Phase 3, Open-label, Randomised Study of Datopotamab Deruxtecan (Dato-DXd) Versus Investigator's Choice of Chemotherapy in Patients Who Are Not Candidates for PD-1/PD-L1 Inhibitor Therapy in First-line Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION Breast02) | AstraZeneca | CHU DE QUEBEC - UNIVERSITÉ LAVAL CENTRE UNIVERSITAIRE DE SANTÉ MCGILL (CUSM) CISSS MONTÉRÉGIE CENTRE / HÔPITAL CHARLES-LEMOYNE | In recruitment |
| HR- & HER2- (triple negative) | TROPION-Breast-03 A Study of Dato-DXd With or Without Durvalumab Versus Investigator’s Choice of Therapy in Patients With Stage I-III Triple-negative Breast Cancer Without Pathological Complete Response at the Time of Surgery Following Neoadjuvant Therapy | AstraZeneca | CIUSSS DU CENTRE-OUEST-DE-L'ILE-DE-MONTREAL / HOPITAL GENERAL JUIF CHU DE QUEBEC - UNIVERSITÉ LAVAL CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CHUM) CENTRE UNIVERSITAIRE DE SANTÉ MCGILL (CUSM) | In recruitment |
| HR+ & HER2- | CELC-G-301 (Description en français à venir) Phase 3, Open-Label, Randomized, Study Comparing Gedatolisib Combined With Fulvestrant & With or Without Palbociclib to Standard-of-Care Therapies in Patients With HR-Positive, HER2-Negative Advanced Breast Cancer Previously Treated With a CDK4/6 Inhibitor in Combination w/Non-Steroidal Aromatase Inhibitor Therapy | Celcuity | CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CHUM) CIUSSS DE L'EST-DE-L'ILE-DE-MONTREAL/ HOPITAL MAISONNEUVE-ROSEMONT CIUSSS SAGUENAY-LAC-ST-JEAN / HÔPITAL DE CHICOUTIMI | In recruitment |
| HR+ & HER2- | CAMBRIA-1 (Description en français à venir) A Phase III, Open-Label, Randomised Study to Assess the Efficacy and Safety of Extended Therapy With Camizestrant Versus Standard Endocrine Therapy (Aromatase Inhibitor or Tamoxifen) in Patients With ER+/HER2- Early Breast Cancer | Astra Zeneca | CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CHUM) CENTRE UNIVERSITAIRE DE SANTÉ MCGILL (CUSM) CIUSSS DE L'EST-DE-L'ILE-DE-MONTREAL/ HOPITAL MAISONNEUVE-ROSEMONT | In preparation |
| HR- & HER2- (triple négatif) | TROPION-B04 A Phase III, Open-label, Randomised Study of Neoadjuvant Datopotamab Deruxtecan (Dato DXd) Plus Durvalumab Followed by Adjuvant Durvalumab With or Without Chemotherapy Versus Neoadjuvant Pembrolizumab Plus Chemotherapy Followed by Adjuvant Pembrolizumab With or Without Chemotherapy for the Treatment of Adult Patients with Untreated Triple-Negative or Hormone Receptor low/HER2-negative Breast Cancer | Astra Zeneca | CIUSSS DU CENTRE-OUEST-DE-L'ILE-DE-MONTREAL/ JEWISH GENERAL HOSPITAL CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CHUM) CENTRE UNIVERSITAIRE DE SANTÉ MCGILL (CUSM) CIUSSS DE L'EST-DE-L'ILE-DE-MONTREAL/ HOPITAL MAISONNEUVE-ROSEMONT CIUSSS DE L'ESTRIE - CHUS CISSS DE CHAUDIÈRE-APPALACHES | In recruitment |
| HR+ & HER2- | INAVO-121 A Phase III, Multicenter, Randomized, Open-Label Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Versus Alpelisib Plus Fulvestrant in Patients With Hormone Receptor-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Who Progressed During or After CDK4/6 Inhibitor and Endocrine Combination Therapy | Hoffmann-LaRoche | CIUSSS DU CENTRE-OUEST-DE-L'ILE-DE-MONTREAL / HOPITAL GENERAL JUIF CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CHUM) CIUSSS DE L'EST-DE-L'ILE-DE-MONTREAL / HOPITAL MAISONNEUVE-ROSEMONT CIUSSS DU NORD-DE-L’ÎLE-DE-MONTRÉAL / HÔPITAL DU SACRÉ-CŒUR-DE-MONTRÉAL | In recruitment |
| HR+ or HR- & HER2+ | INAVO-122 A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo As Maintenance Therapy After First Line Induction Therapy in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer | Hoffmann-LaRoche | CIUSSS DU CENTRE-OUEST-DE-L'ILE-DE-MONTREAL / HOPITAL GENERAL JUIF CHU DE QUEBEC - UNIVERSITÉ LAVAL CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CHUM) CIUSSS DU NORD-DE-L’ÎLE-DE-MONTRÉAL / HÔPITAL DU SACRÉ-CŒUR-DE-MONTRÉAL | In recruitment |
| HR+ & HER2- | pionERA Breast Cancer A Phase III, randomized, open-label multicenter study that will evaluate the efficacy and safety of giredestrant compared with fulvestrant, both in combination with the investigator's choice of a CDK4/6 inhibitor (palbociclib, ribociclib or abemaciclib), in participants with estrogen receptor-positive (ER+), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer who have developed resistance to adjuvant endocrine therapy. | Hoffmann-LaRoche | CHU DE QUEBEC - UNIVERSITÉ LAVAL CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CHUM) CENTRE UNIVERSITAIRE DE SANTÉ MCGILL (CUSM) CIUSSS SAGUENAY-LAC-ST-JEAN / HÔPITAL DE CHICOUTIMI | In recruitment |